منابع مشابه
The Fas ligand/Fas system in renal injury.
The FasL-Fas system regulates renal cell apoptosis, as well as the immune and inflammatory responses. Evidence that FasL and Fas participate in renal injury may be summarized along modified Koch's postulates (Table 1): (i) FasL is expressed by renal cells and during renal injury, (ii) activation of the Fas receptor promotes apoptosis of cultured renal cells, (iii) Fas agonists induce glomerular...
متن کاملthe role of fas/fas ligand system in the pathogenesis of liver cirrhosis and hepatocellular carcinoma
background the fas receptor/ligand system including soluble forms is the most important apoptotic initiator in the liver. dysregulation of this pathway may contribute to abnormal cell proliferation and cell death and is regarded as one of the mechanisms preventing the immune system from rejecting the tumor cells. objectives to analyze the role of fas system fas/ fas ligand (fas/ fasl) in the mu...
متن کاملThe Renal Protective Effects of Corn Silk and Feijoa by using in situ Rat Renal System
Background: Corn silk (CS) is widely used in Iranian traditional medicine and Feijoa sellowiana(FS) is a native plant widespread in the Southern parts of Iran. The aim of the present study was to assess renal protective activities of CS and FS against dosage induced injury by ecstasy (MDMA) using insitu rat renal perfusion (IRRP) system.Methods: Hydro-alcoholic extract of CS and FS (10, 20, 40 ...
متن کاملAbsence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection.
Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration ...
متن کاملp38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice.
The phosphorylation of p38 mitogen-activated protein kinase (MAPK) is responsible for the production and signal transduction of cytokines and chemokines. This study hypothesized that p38 MAPK activation is required for spontaneous autoimmune renal injury in MRL-Fas(lpr) mice, resembling human lupus erythematosus. FR167653, a specific inhibitor of p38 MAPK, is orally administrated from 3 or 4 mo...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 1999
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/14.8.1831